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Epipedobates Tricolor

Transcript: The Poison Size: 2-3 cm Diet - small arthropods, including insects like fruit flies and ants. A high majority is of Pumiliotoxin-containing ants (1). Location - Forests of southwestern Ecuador and northwestern Peru (2). Life Cycle - Eggs hatch and the male frog brings the tadpoles to the water where they grow into adult frogs. Family Tree - Animalia Chordata Amphibians Anura (Frogs) Dendrobatidae (Poisonous Frogs) Epipedobates Tricolor Defensive Weapon - The phantasmal poison frog secretes an alkaloid from its skin. The frog accumulates the alkaloids from the many ants that it eats. It will only produce its poison if fed the right ants in captivity. Frogs that are captured maintain poison levels for years (1). The poison is called epibatidine, named in honor of the frog. If an organism brushes the frog, the poison will be absorbed in through the skin. The LD50 of epibatidine is .4 µg, which is 200x more potent than morphine 1. Saporito, R., Garraffo, H. M., Donnelly, M., Edwards, A., Longino, J., & Daly, J. (2004, May 5). Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419554/ 2. Poison frogs: Dendrobatidae - phantasmal poison frog (epipedobates tricolor). (n.d.). Retrieved from http://animals.jrank.org/pages/152/Poison-Frogs-Dendrobatidae-PHANTASMAL-POISON-FROG-Epipedobates-tricolor-SPECIES-ACCOUNTS.html 1. Strong, S. (1998, May 1). Altering chemistry: Epibatidine a novel alkaloid. Retrieved from http://wwwchem.csustan.edu/chem4400/sjbr/strong98.htm This means that .4 µg is enough to kill 50% of a population (3). Natural History Histrionicotoxin is very similar to epibatidine Phantasmal Poison Frog 1. Daly, J., Secunda, S., Garraffo, H., Spande, T., Wisnieski, A., & Cover, J. (1994, June 6). An uptake system for dietary alkaloids in poison frogs (dendrobatidae). Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/7940573 2. Strong, S. (1998, May 1). Altering chemistry: Epibatidine a novel alkaloid. Retrieved from http://wwwchem.csustan.edu/chem4400/sjbr/strong98.htm 3. Louissaint, P. (2008, September 18). Epibatidine: Nature’s pain reliever. Retrieved from http://chemgroups.ucdavis.edu/~shaw/CHE_150_2008/DHC-Website/Epibatidine_LouissaintP.pdf Mode of Action (2) (1) Lets learn about this little fella. Epibatidine binds to a neuronal nicotinic receptors in the brain. This desensitizes the receptor from receiving any of the natural ligand, acetyl choline (1). This effectively shuts down the muscle control system and paralyzes the victim, leading to die of asphyxiation. Accidental poisonings of humans are treatable by putting them on a ventilator until the effects of the poison wear off. There is no medical uses of epibatidine, but a compound that was synthesized from it called ABT - 594 is being tested for a pain relieving medicine (1). Epipedobates Tricolor

TriColor Initiatives

Transcript: TriColor Initiatives TCI? Unique Edge?? What is it going to be? TCI Skills and knowledge: What do I know Comprehensive knowledge of both the Salesforce and Mulesoft platforms Deep understanding of how mule cost structures Insight into the mismatch between the services offered and needed Skills and knowledge Clearest Problems Inefficient Use of Resources Service mismatch. Fascinations and passions What am I doing when I am at my happiest? Spending quality time with family, particularly the kids, and going on trips provide a great source of happiness. Fascinations and passions What do my friends and colleagues complain about that I find effortless? Finding solutions to complex problems seems What do other people say I am great at, or comes naturally to me? Ability to make things work, particularly in a technical context. Reputation for being a go-to person when something needs to be done right. Additional passions and interests: Deep passion for the middle class and farmers. Strong aversion to poor service in any context Why now? Rapid Digital Transformation: According to a 2021 report, 88% of IT leaders accelerated their digital transformation initiatives in the wake of the COVID-19 pandemic, And Digital Transformations on an average goes for 5+ years Increasing Demand for Client-centric IT Services: Report from Microsoft found that 96% of customers say customer service is an important factor in their loyalty to a brand. This reinforces the market need for a more client-focused approach in the IT services industry Why now? Regulatory Changes and Business Adaptability: Report from Gartner found that by 2023, 65% of the world’s population will have its personal information covered under modern privacy regulations, up from 10% in 2020. This indicates an increasing need for businesses to comply with complex data privacy regulations Customer Discovery Jobs to be Done Top Problems Solutions Value Proposition Customer Discovery Problems Problems Solutions Solutions Value Proposition TCI addresses the pain-points of complex IT challenges and upskilling, providing efficiency, peace of mind, and increased team competency, Value Proposition by delivering tailored Mulesoft solutions, 24/7 support and on-demand training that differentiate us from traditional IT service providers. Risky Assumptions Delivery Side Client Acquisition Side Current State Risky Assumptions Delivery Side Delivery Client Side Clients Current State Client Acquisition and Retention: I can effectively attract new clients, satisfy their needs with my services, and retain them over the long term. Sales Rep Relationships and Referral Consistency: I can establish strong relationships with Mulesoft sales reps who will consistently refer clients to me. Current State Reputation Building and Competitive Differentiation: I can build a strong reputation among other Mulesoft partners and differentiate my services in a meaningful way. Lean Canvas Lean Canvas First Iteration Stuff Current State V 0.1 V 0.1 Stuff Stuff Talking to people - MOM Tests Reading reports. Talking to Experts OneDay Teachings SF PAMs and AEs The Lean Canvas V 1.0 Overstatement and underperformance of Mulesoft tasks by service providers. Difficulty for service providers in adhering to client procedures and standards. Unexpected rise in the costs of Mulesoft licenses. Heads of Mulesoft verticals within non-IT companies. Senior IT Project Managers overseeing Mulesoft projects. IT leaders in companies undergoing digital transformation. A team committed to fulfilling client requirements while minimizing license costs. My way of working on Mulesoft, the way in which we can deliver what matters keeping the reduced license cost. Thinking in terms of Mulesoft, Not JAVA or SF. Mulesoft license cost optimization strategies provided. Highly competent team aligned with client needs and desires. Unique focus on Mulesoft, unlike other providers who integrate it with Salesforce or JAVA. Client API traffic/license usage. Duration of client retention. Number of clients experimenting with other vendors but returning to our services. Ratio of successfully delivered projects to total projects undertaken. Mulesoft/SF Partner Account Manager and Account Executives. Events Cold Emails + LinkedIn Provision of services. Consultancy offerings. Support through Catalyst. Training programs. Employee remuneration costs. Expenditure on training and certification programs. Costs associated with internal projects. Expenses related to employee welfare and satisfaction Great IT services The best IT Services Provider Initiatives Ton of Great Executions Enhanced Farmer Income Enhanced Middle Class standards . . . . . A better and a more sustainable world

Background Presentation

Transcript: 14th Week Consulting interns can be expensive Time and Money Personal Experience Preliminary Design Stage NFPA 101 and NFPA 13 New and Existing Education, Business, and Mercantile Definition of Project This app would be used to provide interns and recent graduates with an outline of guidelines for how to design and review designs of specific occupancies. With the given time frame, I will be writing the information that will go into the app Begin parametric study: Speak with my mentor and Jason to understand more about what critical variables I could concentrate on for this app. Choose those parameters and begin my study Gather information from NFPA 101 and NFPA 13 for new and existing education, business, and mercantile occupancies. By: Breanne Thompson Next Steps (Continued) Finish preparing for Draft of Analysis Pull together and discuss results of project Draw my conclusions and state future work needed Turn in Final Paper! 10th and 11th Week Turn in my parametric study Begin draft of analysis Map out the process of the app for the key elements 15th Week References Next Steps 7th Week Prepare for Final Presentation Summarize my draft of analysis into presentation Work on how to incorporate a live demonstration for my presentation App Development Background Information 8th-9th Week Continuous Process Objective-C for Apple products Java for Android products 6 months of studying Places to Learn: Codecademy, iOS Dev Center, Android Developers Training Hire App Developer will cost thousands Prepare Final Paper Dive into Shark Tank! 1. http://lifehacker.com/5401954/programmer-101-teach-yourself-how-to-code 2. http://www.bluecloudsolutions.com/blog/cost-develop-app/ 6th Week Background Presentation 12th-13th Week

Background Presentation

Transcript: Real action and accountability Amnesty International Non-state actors/ Rebel Groups?? ...and what about men?? ignoring male rape victims? would rape exist without a man? Weapons of War: Rape UN as an Arena - NGO's - Discussion and dialogue Arena Instrument Actor Critical Thinking Weapons of War: Rape UN as an instrument UNSC Resolution 1820 (2008) UN as an Actor - UN Action Against Sexual Violence in Conflict Weapons of War: Rape Problems with 1820 "Roles and Functions of International Organizations" "Sexual violence, when used as a tactic of war in order to deliberately target civilians or as a part of a widespread or systematic attack against civilian populations, can significantly exacerbate situations of armed conflict and may impede the restoration of international peace and security… effective steps to prevent and respond to such acts of sexual violence can significantly contribute to the maintenance of international peace and security" (UNSC Resolution 1820, p. 2)" http://www.stoprapenow.org/uploads/advocacyresources/1282164625.pdf Background Presentation- Kristin Mann Weapons of War: Rape Brief Insight - used to manipulate social control - destabilize communities - weaken ethnic groups and identities Examples: - Sudanese Militia - Rwanda Genocide - DRC Critical Thinking http://www.womenundersiegeproject.org/blog/entry/the-need-for-numbers-on-rape-in-warand-why-theyre-nearly-impossible-to-get Critical Thinking Increased Data Collection by international organizations - determine humanitarian responses - ensures justice and reparation - provides recognition and dignity

Background Presentation

Transcript: Death rate 2012: 12.84 deaths/1,000 population (World ranking: 22) Infant (Child Mortality) Total: 79.02 deaths/1,000 live births (world ranking: 10) HIV/AIDS (2) Appropriate Technology Landlocked country Great African Rift Valley system: East – Lake Malawi South – mountains, tropical palm-lined beaches Mainly a large plateau, with some hills Lake Malawi (Lake Nyasa) Almost 1 million people have AIDS 60% of these are female Declining in urban areas, Rising in rural areas Leading cause of death amongst adults Contributes to the low life expectancy: 54.2 years 209th ranking (One of the lowest) 500,000 children have been orphaned due to AIDs Micro-finance Policy Framework and Strategies (Health SWAp) increasing the availability and accessibility of antenatal services; utilization of skilled health personnel during pregnancy, childbirth and postnatal period at all levels of the health system; strengthening the capacity of individuals and institutions to improve maternal and neonatal health; increasing the number of skilled health personnel; constructing and upgrading health facilities to offer essential health services particularly focusing on rural and underserved areas; and provision of ARVs and micronutrients during pregnancy. Geography of Malawi CCST 9004 Appropriate Technology for the Developing World Indicator 3: Literacy Rate of 15 – 24 year-olds According to the World Bank, microfinance is defined as: Microfinance is the provision of financial services to the entrepreneurial poor.This definition has two important features:it emphasizes a range of financial services—not just credit— and it emphasizes the entrepreneurial poor. Goal 2: Achieve Universal Primary Education Appropriate Technology: SIRDAMAIZE 113 Population: 16,777,547 (estimated in July 2013) Population growth rate: 2.758% (2012 est.) (World ranking: 18) Age structure Children: 50% of total population HIV/AIDS Human Resources Education Poverty Food Insecurity Erratic Rainfall Patterns/Droughts Corruption Lack of Foreign Investment Languages Indicator 5: Proportion of seats held by women in National Parliaments Central Region: 1-9 (Yellow) *Capital: Lilongwe Northern Region: 10-15 (Red) Southern Region: 16-27 (Green) Lake Malawi (Blue) Land surface area 45,747 square miles Challenges: · shortage of qualified primary school teachers; · inadequate physical infrastructure; · poor retention of girls mainly from standard five to eight; · high disease burden due to HIV and AIDS consequently leadinto absenteeism, especially among girls who take care of the sick · Poverty levels are high in rural areas. Malawi – Climate/Agriculture Trading partners: South Africa, Zambia, China, US Challenges: · shortage of qualified primary school teachers; · inadequate physical infrastructure; · poor retention of girls mainly from standard five to eight; · high disease burden due to HIV and AIDS consequently leading to absenteeism especially among girls who take care of the sick; and · poor participation of school committees and their communities in school management. · Poverty levels are high in rural areas. 1 Doctor per 50,000 people Hinders the ability to deliver medical services to people in need Reason: Emigration Lack of access to education Aggravated by AIDS > 4 nurses are lost each month This also affects other sectors: Government Business Farmers Human Resources HIV/AIDS - Contemporary GDP: US $14.58 billion (2012 est.) (World ranking: 142) Labor force: agriculture: 90%; industry and services: 10% (2003 est.) Countries main income Agriculture Main crops: maize, tobacco, tea, sugar cane, groundnuts, cotton, wheat, coffee, and rice Industry: tobacco, tea, sugar, sawmill products, cement, consumer goods Challenges: limited capacity in terms of human and material resources to facilitate adult literacy and continuing education; early marriages perpetuated by socioeconomic factors; socio–cultural factors that make people believe that men should be leaders while women are followers; and, poor learning environment which affects girls in primary and secondary schools e.g. sanitary facilities, long distances to education facilities, extra burden from domestic chores especially for adolescent girls resulting into high dropout rate. 1964: Independent from Britain Indicator 1: Maternal Mortality Ratio Malawi Demographics Problems - Outline Indicator 4: Share of Women in Wage Employment in the Non- Agriculture Sector measure of employment opportunities ( i.e equal proportions of men and women in formal employment) Yet, more women participate in the agriculture sector than in the formal wage employment especially in jobs that require professional qualifications. Due to: literacy levels, gender disparity and cultural values. Facts About the Product: Drought tolerant maize variant Able to mature under limited rainfall Suitable for marginal rainfall areas 136 days to mature Normally: 150 – 180 days Able to mature under limited rainfall Suitable for marginal rainfall areas

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